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Probably many children were born to Adam during his long life; the ancient quibble about "Cain's wife" is easily resolved in terms of brother/sister marriages in the first generation. Close marriages are genetically dangerous today because of the accumulation of harmful mutations in the human genetic system over many generations, and incest has been prohibited since Moses' time (Leviticus 20:11-20). In the first few generations, including those after the flood, marriages of near relatives were necessary in order for mankind to obey God's command to "multiply" (Genesis 1:28; 9:1).
KJV Defenders Study Bible, by Dr. Henry Morris, Ph.D.
Publisher: Thomas Nelson
DEF 10 ISBN 0-529-10444-x
DEF 10-1 ISBN 0-529-10445-8