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The same cautions apply to any discussions of the fruit of the tree of knowledge of good and evil, which likewise was genuinely physical. It is conceivable that the fruit contained substances capable of catalyzing physiological decay processes in the body, perhaps affecting even the genetic system. Whether or not this was the case, a "knowledge" of evil would necessarily follow its eating, since evil is fundamentally rejection of God's Word. Man had abundant knowledge of good already since everything God had made was "very good" (Genesis 1:31), but disobedience would itself constitute an experimental knowledge of evil.
KJV Defenders Study Bible, by Dr. Henry Morris, Ph.D.
Publisher: Thomas Nelson
DEF 10 ISBN 0-529-10444-x
DEF 10-1 ISBN 0-529-10445-8