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The specific symbolism of the passover required the absence of leaven, which symbolizes a corrupting influence. Leaven is associated with fermentation which is a process of decay (thus representative of God's curse on the earth) and is also connected with the production of the toxic substance, alcohol.
KJV Defenders Study Bible, by Dr. Henry Morris, Ph.D.
Publisher: Thomas Nelson
DEF 10 ISBN 0-529-10444-x
DEF 10-1 ISBN 0-529-10445-8